Somatic mutation or epigenetic modification - Somatische Mutation oder epigenetische Modifikation
نویسندگان
چکیده
منابع مشابه
Somatic Mutation and Autoimmunity
Upon reading Christopher Goodnow’s recent Review article in Cell, which emphasized the overlapping role of somatic mutation in autoimmunity and cancer (Goodnow, 2007), I was reminded of a graduate lecture course given by Professor Roderick MacLeod in 1995 at the University of Illinois. While introducing F.M. Burnet’s clonal selection theory to our small class, Professor MacLeod mentioned Burnet...
متن کاملComparing somatic mutation-callers
Background: Somatic mutation-calling based on DNA from matched tumor-normal patient samples is one of the key tasks carried by many cancer genome projects. One such large-scale project is The Cancer Genome Atlas (TCGA), which is now routinely compiling catalogs of somatic mutations from hundreds of paired tumor-normal DNA exome-sequence data. Nonetheless, mutation calling is still very challeng...
متن کاملMitochondrial DNA Somatic Mutation in Cancer
Cancer cells are known to drastically alter cellular energy metabolism. The Warburg effect has been known for over 80 years as pertaining cancer-specific aerobic glycolysis. As underlying molecular mechanisms are elucidated so that cancer cells alter the cellular energy metabolism for their advantage, the significance of the modulation of metabolic profiles is gaining attention. Now, metabolic ...
متن کاملCoherent Somatic Mutation in Autoimmune Disease
BACKGROUND Many aspects of autoimmune disease are not well understood, including the specificities of autoimmune targets, and patterns of co-morbidity and cross-heritability across diseases. Prior work has provided evidence that somatic mutation caused by gene conversion and deletion at segmentally duplicated loci is relevant to several diseases. Simple tandem repeat (STR) sequence is highly mu...
متن کاملSomatic mutation and the Antarctic ozone hole
1 Previous studies of Antarctic clonal moss populations using RAPD markers have reported extraordinarily high levels of genetic variation. This has been claimed to reflect somatic mutation, possibly resulting from elevated UV-B radiation. 2 Our study used microsatellite markers to compare the genetic variation present within continental Antarctic, sub-Antarctic and temperate populations of the ...
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ژورنال
عنوان ژورنال: Journal of Science, Humanities and Arts - JOSHA
سال: 2017
ISSN: 2364-0626
DOI: 10.17160/josha.4.6.370